@thecookdebra As a woman with PCOS that is the reason we cannot get pregnant, I respectfully comment that vitamin and mineral deficiencies do not affect fertility that massively. Holistic treatments are normally unproven and can be harmful to fetus.
Has she had had her insulin checked? She could be insulin resistant. Your cells need glucose for energy, but when we eat we spike it. Insulin is released by the liver to help the cell uptake glucose. When you are insulin resistant, which is quite common with PCOS, the cells do not respond well to insulin. The glucose stays in your blood vessels, eventually stored as fat. It wrecks havoc on our bodies, including fertility. If she hasn't had a metabolic panel, she should. I lost 30+ pounds with the help of a weight management specialist and now I am ovulating. It is worth a shot with you two. Her inability to lose weight is making me suspicious for either insulin resistance or a thyroid issue, but I am not a medical doctor.
Also, I acknowledge the frustration. Some couples get pregnant by accident - and it makes you feel useless.
Have you tried IUI? What conversations have you had with your RE? Sometimes if you don't lead with a question, they don't touch on it. I'm constantly asking my RE questions on my end that he likely would not have mentioned. Not because he doesn't care, but because he normalizes these results. They are commonplace to him... It's easy to forget that not everyone grasps their situation.
That was long but I truly do wish you luck. You're absolutely not alone. Your wife might also feel at home with the PCOS TTC subreddits, and you might get a lot of insight as well.
She has been reluctant to do IVF because of the "everyone else gets pregnant the natural way but I have to spend thousands of dollars to achieve it..." Which just wrecks her mental health.