High PAPP-A *AND* low beta-hCG

[stan783]

Hi everyone, I just received my blood test results and I wonder what does such combination of PAPP-A and beta-hCG indicate, I googled a bit but I couldn't find anything but I'm pretty sure it's not typical.

beta-hCG 38,3 iu/l, 0.675 MoM

PAPP-A 4,71 iu/l, 2.197 MoM

Hope anyone has some info. 11.2 gestational week, CRL 50.

 

[justtrying25]

@stan783 Wait, you’re 11 weeks pregnant with a 38.3hcg?

 

[stevekolt]

@justtrying25 No, this is a different blood test. It’s not like a “normal” HCG.

ETA: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547446/

I actually understand very little about this blood test but I had it drawn as part of my NIPT testing.

OP, I’d go to the NIPT subreddit, they may be able to help you there.

 

[stan783]

@stevekolt yes, this was the kind of test like the one you linked to. thanks for the suggestion, I'll try on NIPT sub.

 

[vanniek]

@stan783 Was this for your combined screening? I had similar results and was referred for additional screening (NIPT, etc). The combined blood test is not remotely diagnostic, but these results possibly indicate more investigation is needed.

 

[stan783]

@vanniek yes, that's what I'm going to do (NIPT).
I understand the opposite results (high beta, low pappa) indicate certain risks, just wondered what about the combination I have.

hope your results will be good.

 

[vanniek]

@stan783 Thank you - this happened to me earlier this year. Read ahead if you would like to know how it went for me.
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TW - baby loss
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I had a high risk NIPT for Trisonomy 18 that was ultimately diagnosed with an amnio. I chose to TFMR at 17 weeks.