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@barbraa Individuals with MTHFR polymorphisms process folic acid without issue, this has been explicitly tested: https://www.cdc.gov/ncbddd/folicacid/mthfr-gene-and-folic-acid.html There are no concerning safety issues with folic acid supplementation and outstanding evidence that folic acid...

@erictolliver There is outstanding clinical trial evidence that folic acid supplementation decreases spina bifada occurrence in fetuses. There is scientifically informed conjecture that l-methylfolate would likely be equivalent to folic acid and maybe could be better for some people. But plenty...