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  1. M

    Our RE just made me feel like we are "barren"...completely shocked and a little lost

    @krython Oh, for sure, in SI units that would be a problematic value. OP has posted her FSH and LH now — not sure if they were there when you posted your first comment.
  2. M

    Around the uterus in fourteen days: the luteal phase

    @danyellem They vary from person to person -- my classic progesterone symptoms are tender breasts, moodiness, and weird dreams, and others commonly report things like cramping, nausea, various GI symptoms, [probably others I'm not thinking of right now]. Progesterone doesn't have to cause...
  3. M

    Around the uterus in fourteen days: the luteal phase

    @okmnhyxxx Probably a little of column A, a little of column B. Some are likely wrong about their ovulation day. But it’s not impossible to get a positive at 8dpo — about 30% of embryos undergo implantation at 8dpo or earlier. Most of those won’t have high enough hCG levels to be positive at 8dp...
  4. M

    New research says average cycle isn't 28 days (and water is wet, etc)

    @missourian101 ...incidentally, and sorry for the double-reply, I just realized another paper I've been kicking around recently (this one), which involved about 1000 subjects, also found a modal LP of 12 days (see Figure 3), and a modal day of ovulation of CD16 for 28-day-cycle-having subjects...
  5. M

    Optimizing natural fertility: review of recommendations

    We see a lot of questions about what people need to do to optimize their odds for each cycle, and, fortunately, there's actually a reasonable amount of evidence-based advice out there. This information is primarily coming from the American Society for Reproductive Medicine’s committee opinion...
  6. M

    Our RE just made me feel like we are "barren"...completely shocked and a little lost

    @krython OP's AMH is right around 25th percentile for age 33 -- it's a little lower than average, sure, but not DOR territory?
  7. M

    New research says average cycle isn't 28 days (and water is wet, etc)

    @missourian101 I don't know, and I do wish they had presented medians and histograms, totally agreed. It's clear that the mean cycle length is skewed rightward by people with longer cycles -- they have about twice as many people in the 31-35-day cycle range than the 15-20 and 21-24-day cycle...
  8. M

    Around the uterus in fourteen days: the luteal phase

    @mickiio Could be either! Tubal damage does increase the likelihood of an ectopic, and there are likely cases where there's subtle damage that goes undetected, but is still capable of blocking an embryo's way to the uterus. For example, cigarette smoking is a risk factor for ectopic pregnancy...
  9. M

    New research says average cycle isn't 28 days (and water is wet, etc)

    A great new paper of interest to the sub came out this week, and I wanted to draw attention to it and discuss it. Original research paper here A variety of popular press articles about the paper here Title: Real-world menstrual cycle characteristics of more than 600,000 menstrual cycles What...
  10. M

    Around the uterus in fourteen days: the luteal phase

    @sls2labs Yes, precisely! They can’t undergo implantation until they’re developmentally ready. So they’ll undergo implantation at the normal time, or potentially a little late — the thing about them being not located in the uterus means they generally don’t grow as well as uterine pregnancies...
  11. M

    UPDATE on 16-day old post on Intimate Assault by Stranger 2ce and Unprotected Sex w/ Boyfriend

    @franiljanren Am I correct that the sex (consensual and rape) that you're concerned about took place more than four weeks ago? If so, then an hCG blood test result
  12. M

    Around the uterus in fourteen days: the luteal phase

    @jschoeman00 Awesomely enough, one of the major signals that sperm use to tell them when and where to go is progesterone itself. This has the dual advantage of telling them that ovulation has happened and also which direction they should swim. Anything that would cause the death of enough cells...
  13. M

    What the OPK ratio levels really tell you: peaks vs. positives

    @prelude4ws Which drives me nuts, because people are like, you can't use FMU EVER!!! But "this is true for 50% of people" does not justify a rigid rule.
  14. M

    Our RE just made me feel like we are "barren"...completely shocked and a little lost

    @deojames I mean, the thing is that an RE could get you pregnant if you have totally normal fertility, but that doesn’t imply that you need an RE to get pregnant.
  15. M

    Around the uterus in fourteen days: the luteal phase

    @hal16 Just chilling! I should have linked this picture, which I love, from the developmental bio text I use in class: panel B is three intrepid pre-implantation blastocysts going on a journey through the uterus.
  16. M

    Around the uterus in fourteen days: the luteal phase

    Today we are going to discuss a time of mystery, a time of endless possibility, a time of progesterone: the luteal phase. (Despite my clickbait title, the length of the typical luteal phase can vary from about 10 to about 16 days, and 12 days is actually the most common length. Don’t believe...
  17. M

    What the OPK ratio levels really tell you: peaks vs. positives

    @prelude4ws Love this, wabbit! Thanks for writing it up.
  18. M

    Our RE just made me feel like we are "barren"...completely shocked and a little lost

    @deojames After trying for three or four cycles with these numbers, I would absolutely not move straight to IVF. You have a great chance of conceiving within a perfectly normal timeframe -- it's worth playing out those odds and seeing what happens.
  19. M

    Progesterone: to take or not to take?

    @kevinh So in this case, even if the implantation window was shifted earlier, the embryo itself wouldn't be ready for implantation -- ectopic pregnancy doesn't happen because implantation happens too soon in the timeline. The embryo is not ready for implantation until it reaches the blastocyst...
  20. M

    B12 came out high 848 pmol/L

    @j87 Just to reframe a bit here -- these kinds of studies can generally say that (very) high levels of maternal blood folate are associated with an increased risk of autism spectrum disorders in children, but not that high levels are causative. There could very easily be genetic influences...
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